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For the full-cost-effectiveness study, Gail R. Osterman and two other colleagues at New York University School of Medicine analyzed the relationship between tamoxifen use and breast cancer incidence. The researchers followed 3,927 women age 41 to 67 with breast cancer between 1980 and 2007, they measured tamoxifen use at the outset of study and again during the period.
As expected, overall breast cancer incidence was inversely related to tamoxifen use. Women younger than 45 years who took Tamoxifen at least a couple of times year had a 10% lower risk of breast cancer than women who used the drug less than a couple times year.
But the researchers found that relationship between tamoxifen use and cancer progression (cancer spreading to other parts of the body) was much more complicated: While tamoxifen use could potentially prevent breast cancer from becoming invasive and advancing to a more advanced stage, the risks outweighed benefits in women their mid-60s who took the drug once a month. In other words, if there was a problem that started in the breast, tamoxifen for sale online there was a way to treat it with tamoxifen.
Women over the age of 65 who used tamoxifen five or more times a year had 40% chance of dying breast cancer, compared with just 12.5% for the women who used tamoxifen less than five times a year. Of the women over 65 diagnosed with breast cancer, the risk of dying from disease was about 15% higher among women who used tamoxifen every day than among those who did not.
The researchers said that findings suggest physicians should inform patients of the possible benefits and drawbacks of tamoxifen use, in particular for women their mid-60s and older.
For the full-cost-effectiveness study, Osterman and co-authors analyzed data on women diagnosed with invasive breast cancer in 2001 and 2008 then followed them until 2010. They calculated the number of lives saved and lifetime medical costs for each additional year of tamoxifen use. Overall, they estimated that the drug saves $8.1 million in annual medical costs for women treated with ta